| http://purl.uniprot.org/citations/24453333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24453333 | http://www.w3.org/2000/01/rdf-schema#comment | "The β subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 α1 subunits and thus contribute to neuronal excitability, neurotransmitter release, and calcium-induced gene regulation. In addition, certain β subunits are targeted into the nucleus, where they interact directly with the epigenetic machinery. Whereas their involvement in this multitude of functions is reflected by a great molecular heterogeneity of β isoforms derived from four genes and abundant alternative splicing, little is known about the roles of individual β variants in specific neuronal functions. In the present study, an alternatively spliced β4 subunit lacking the variable N terminus (β4e) is identified. It is highly expressed in mouse cerebellum and cultured cerebellar granule cells (CGCs) and modulates P/Q-type calcium currents in tsA201 cells and CaV2.1 surface expression in neurons. Compared with the other two known full-length β4 variants (β4a and β4b), β4e is most abundantly expressed in the distal axon, but lacks nuclear-targeting properties. To determine the importance of nuclear targeting of β4 subunits for transcriptional regulation, we performed whole-genome expression profiling of CGCs from lethargic (β4-null) mice individually reconstituted with β4a, β4b, and β4e. Notably, the number of genes regulated by each β4 splice variant correlated with the rank order of their nuclear-targeting properties (β4b > β4a > β4e). Together, these findings support isoform-specific functions of β4 splice variants in neurons, with β4b playing a dual role in channel modulation and gene regulation, whereas the newly detected β4e variant serves exclusively in calcium-channel-dependent functions."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3935-13.2014"xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Kofler R."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Flockerzi V."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Geley S."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Lusser A."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Flucher B.E."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Koschak A."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Obermair G.J."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Benedetti A."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Stanika R."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Di Biase V."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Wille A."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Etemad S."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Bindreither D."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/author | "Burtscher V."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/pages | "1446-1461"xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/title | "Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression."xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24453333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24453333 |
| http://purl.uniprot.org/citations/24453333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24453333 |
| http://purl.uniprot.org/uniprot/#_A0A087WPP1-mappedCitation-24453333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24453333 |