| http://purl.uniprot.org/citations/2445752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2445752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2445752 | http://www.w3.org/2000/01/rdf-schema#comment | "A full-length clone encoding human chromogranin A has been isolated from a lambda gt10 cDNA library of a human pheochromocytoma. The nucleotide sequence reveals that human chromogranin A is a 439-residue protein preceded by an 18-residue signal peptide. Comparison of the protein sequence of human chromogranin A with that of bovine chromogranin A shows high conservation of the NH2-terminal and COOH-terminal domains as well as the potential dibasic cleavage sites, whereas the middle portion shows remarkable sequence variation (36%). This part of human chromogranin A contains a sequence homologous to porcine pancreastatin at residues 250-301. The sequence variation in this part of human chromogranin A compared to porcine pancreastatin is 32% and thus of the same magnitude as that between human and bovine chromogranin A. Therefore, the difference between porcine pancreastatin and the corresponding portions of bovine or human chromogranin A can be explained by species variation, suggesting that pancreastatin is derived from chromogranin A itself rather than a protein that is only similar to chromogranin A. Moreover, the pancreastatin sequence contained in human chromogranin A is flanked by sites for proteolytic processing. Together, these observations suggest that human chromogranin A may be the precursor for a human pancreastatin molecule and possibly for other, as yet unidentified, biologically active peptides."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)45486-5"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)45486-5"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Huttner W.B."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Huttner W.B."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Gerdes H.-H."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Gerdes H.-H."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Benedum U.M."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Benedum U.M."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Konecki D.S."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/author | "Konecki D.S."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/pages | "17026-17030"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/pages | "17026-17030"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/title | "The primary structure of human chromogranin A and pancreastatin."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/title | "The primary structure of human chromogranin A and pancreastatin."xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/volume | "262"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://purl.uniprot.org/core/volume | "262"xsd:string |
| http://purl.uniprot.org/citations/2445752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2445752 |
| http://purl.uniprot.org/citations/2445752 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2445752 |