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Background

This study was designed to evaluate the clinical benefit of predicting the cyclin D1 (CCND1) status using cell-free plasma DNA in superficial esophageal squamous cell carcinoma (ESCC) patients.

Methods

The ratio of the CCND1 (11q13) dosage to the DRD2 (11q22-23) dosage (C/D ratio) as the CCND1 copy number was evaluated. This study was divided into three steps: (1) demonstration of the feasibility, (2) evaluation of whether the plasma C/D ratio assay could monitor tumor dynamics, and (3) a validation study in 63 consecutive superficial ESCC (pTis-T1) patients and 40 healthy volunteers.

Results

(1) The plasma C/D ratio was significantly higher (p = 0.0369) in superficial ESCC patients than in the controls in a preliminary test. (2) The high plasma C/D ratio appeared to reflect the tumor levels of the CCND1 status and was reduced in postoperative plasma samples (p = 0.1154) and samples following endoscopic resection (p = 0.0845). (3) Validation analysis revealed that the plasma C/D ratio was significantly higher in superficial ESCC patients than in controls (p < 0.0001). The frequency of recurrence was significantly higher (p = 0.0198), and recurrence-free survival was significantly shorter (p = 0.0075) in patients with a high plasma C/D ratio. Moreover, a high C/D ratio was shown to be an independent risk factor for recurrence on multivariate analysis [p = 0.0334; odds ratio 10.58 (range 1.203-93.23)].

Conclusion

The prediction of CCND1 amplification by plasma DNA may be a new complementary clinical biomarker for recurrence in patients with superficial ESCC."xsd:string
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http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Okamoto K."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Kubota T."xsd:string
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http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Konishi H."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Yagi N."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Ichikawa D."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Takeshita H."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Shiozaki A."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Miyamae M."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Otsuji E."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/author"Hirajima S."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/name"Dig Dis Sci"xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/pages"1152-1159"xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/title"Clinical impact of predicting CCND1 amplification using plasma DNA in superficial esophageal squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/24458211http://purl.uniprot.org/core/volume"59"xsd:string
http://purl.uniprot.org/citations/24458211http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24458211
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