| http://purl.uniprot.org/citations/24460703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24460703 | http://www.w3.org/2000/01/rdf-schema#comment | "The AP-2 complex is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during mammalian clathrin-mediated endocytosis. While budding yeast has clear homologues of all four AP-2 subunits which form a complex and localize to endocytic sites in vivo, the function of yeast AP-2 has remained enigmatic. Here, we demonstrate that AP-2 is required for hyphal growth in Candida albicans and polarized cell responses in Saccharomyces cerevisiae. Deletion of APM4, the cargo-binding mu subunit of AP-2, causes defects in pseudohyphal growth, generation of a mating projection and the cell wall damage response. In an apm4 null mutant, the cell wall stress sensor Mid2 is unable to relocalize to the tip of a mating projection following pheromone addition, or to the mother bud neck in response to cell wall damage. A direct binding interaction between Mid2 and the mu homology domain of Apm4 further supports a model in which AP-2 binds Mid2 to facilitate its internalization and relocalization in response to specific signals. Thus, Mid2 is the first cargo for AP-2 identified in yeast. We propose that endocytic recycling of Mid2 and other components is required for polarized cell responses ensuring cell wall deposition and is tightly monitored during cell growth."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.org/dc/terms/identifier | "doi:10.1111/tra.12155"xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/author | "Allwood E.G."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/author | "Ayscough K.R."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/author | "Chapa-y-Lazo B."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/author | "Smaczynska-de Rooij I.I."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/author | "Snape M.L."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/pages | "546-557"xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/title | "Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses."xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/24460703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24460703 |
| http://purl.uniprot.org/citations/24460703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24460703 |
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| http://purl.uniprot.org/uniprot/#_Q99186-mappedCitation-24460703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24460703 |
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