http://purl.uniprot.org/citations/24462208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24462208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24462208 | http://www.w3.org/2000/01/rdf-schema#comment | "XRN2 is an essential eukaryotic exoribonuclease that processes and degrades various substrates. Here we identify the previously uncharacterized protein R05D11.6/PAXT-1 as a subunit of an XRN2 complex in C. elegans. Targeted paxt-1 inactivation through TALEN-mediated genome editing reduces XRN2 levels, decreases miRNA turnover activity, and results in worm death, which can be averted by overexpressing xrn-2. Hence, stabilization of XRN2 is a major function of PAXT-1. A truncated PAXT-1 protein retaining a predicted domain of unknown function (DUF3469) suffices to restore viability to paxt-1 mutant animals, elevates XRN2 levels, and binds to XRN2. This domain occurs in additional metazoan proteins and mediates interaction of human CDKN2AIP/CARF and NKRF/NRF with XRN2. Thus, we have identified a bona fide XRN2-binding domain (XTBD) that can link different proteins, and possibly functionalities, to XRN2."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.01.001"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.01.001"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Richter H."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Richter H."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Grosshans H."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Grosshans H."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Miki T.S."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Miki T.S."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Rueegger S."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/author | "Rueegger S."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/pages | "351-360"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/pages | "351-360"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/title | "PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/title | "PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain."xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/volume | "53"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://purl.uniprot.org/core/volume | "53"xsd:string |
http://purl.uniprot.org/citations/24462208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24462208 |
http://purl.uniprot.org/citations/24462208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24462208 |