| http://purl.uniprot.org/citations/24462895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24462895 | http://www.w3.org/2000/01/rdf-schema#comment | "Alloreactivity to HLA-DP molecules, class II heterodimers of an oligomorphic alpha and a polymorphic beta chain, is increasingly being studied due to its relevance in clinical transplantation. We hypothesized that not only polymorphisms in the peptide binding groove encoded by exon 2 of HLA-DPB1, but also in other regions of the molecule and the alpha chain, could play a role in CD4+ T cell allorecognition. To test this possibility, we comparatively investigated CD4+ T cell allorecognition, measured by upregulation of the activation marker CD137, against HLA-DPB1*13:01, *05:01, *03:01, *17:01 or their allele counter parts DPB1*107:01, *135:01, *104:01, *131:01, with identical exon 2 sequences but polymorphism in exons 1, 3 or 4, in the context of different HLA-DPA1 (DPA1) polymorphisms (DPA1*01:03 and *02:01). No significant differences in CD4+ T cell allorecognition levels could be demonstrated for any of the beyond exon 2 DPB1 variants studied. Interestingly, however, the mean fold change in CD4+ CD137+ cells was significantly higher when the target shared at least one DPA1 allele with the allogeneic stimulator, compared to a distinct DPA1 background (1.65 vs 0.23, P<0.005). Structural homology modeling suggested specific amino acid residues in the alpha chain, in particular position 31, to impact CD4+ T cell allorecognition of HLA-DP. Our data argue against a significant role of beyond exon 2 DPB1 polymorphisms for T cell alloreactivity, but show relevance of DPA1 polymorphism in this mechanism. These new findings impact HLA matching strategies in unrelated stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2013.12.006"xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Crivello P."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Tilanus M.G."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Voorter C.E."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Fleischhauer K."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Groeneweg M."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Lauterbach N."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Wieten L."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/author | "Zito L."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/pages | "19-29"xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/title | "Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain."xsd:string |
| http://purl.uniprot.org/citations/24462895 | http://purl.uniprot.org/core/volume | "59"xsd:string |
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