| http://purl.uniprot.org/citations/24463366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24463366 | http://www.w3.org/2000/01/rdf-schema#comment | "The response of individual animals to mating signals depends on the sexual identity of the individual and the genetics of the mating targets, which represent the mating social context (social environment). However, how social signals are sensed and integrated during mating decisions remains a mystery. One of the models for understanding mating behaviors in molecular and cellular terms is the male courtship ritual in the fruit fly (Drosophila melanogaster). We have recently shown that a subset of gustatory receptor neurons (GRNs) that are enriched in the male appendages and express the ion channel ppk23 play a major role in the initiation and maintenance of male courtship via the perception of cuticular contact pheromones, and are likely to represent the main chemosensory pathway that influences mating decisions by males. Here we show that genetic feminization of ppk23-expressing GRNs in male flies resulted in a significant increase in male-male sexual attraction without an apparent impact on sexual attraction to females. Furthermore, we show that this increase in male-male sexual attraction is sensory specific, which can be modulated by variable social contexts. Finally, we show that feminization of ppk23-expressing sensory neurons lead to major transcriptional shifts, which may explain the altered interpretation of the social environment by feminized males. Together, these data indicate that the sexual cellular identity of pheromone sensing GRNs plays a major role in how individual flies interpret their social environment in the context of mating decisions."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20147369"xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/author | "Ben-Shahar Y."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/author | "Hefetz A."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/author | "Seltzer R."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/author | "Zelle K.M."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/pages | "152-160"xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/title | "Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males."xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/24463366 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24463366 |
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| http://purl.uniprot.org/uniprot/#_P58958-mappedCitation-24463366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24463366 |