| http://purl.uniprot.org/citations/24470497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24470497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24470497 | http://www.w3.org/2000/01/rdf-schema#comment | "On TCR ligation, the adaptor Nck is recruited through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3ε. We have studied the relevance of this interaction for T cell activation in vitro and in vivo by targeting the interaction sites in both partners. The first approach consisted of studying a knockin (KI) mouse line (KI-PRS) bearing a conservative mutation in the PRS that makes the TCR incompetent to recruit Nck. This deficiency prevents T cell activation by Ag in vitro and inhibited very early TCR signaling events including the tyrosine phosphorylation of CD3ζ. Most important, KI-PRS mice are partly protected against the development of neurological symptoms in an experimental autoimmune encephalitis model, and show a deficient antitumoral response after vaccination. The second approach consisted of using a high-affinity peptide that specifically binds the src homology 3.1 domain and prevents the interaction of Nck with CD3ε. This peptide inhibits T cell proliferation in vitro and in vivo. These data suggest that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3ε interaction may represent a target for pharmacological modulation of the immune response."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1203414"xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1203414"xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Suchanek M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Suchanek M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Arellano I."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Arellano I."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Blanco R."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Blanco R."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Borroto A."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Borroto A."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Dopfer E.P."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Dopfer E.P."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Fuentes M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Fuentes M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Orfao A."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Orfao A."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Prouza M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Prouza M."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Schamel W.W."xsd:string |
| http://purl.uniprot.org/citations/24470497 | http://purl.uniprot.org/core/author | "Schamel W.W."xsd:string |