| http://purl.uniprot.org/citations/24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24470505 | http://www.w3.org/2000/01/rdf-schema#comment | "T cells are critical to immunity against pathogenic Salmonella including Salmonella Typhi which causes systemic infection, typhoid, in humans. The strategies that this pathogen employs to keep T-cell mediated immune responses in check during establishment of systemic infection are not completely understood. Here, we show that the virulence polysaccharide Vi, which distinguishes S. Typhi from localized gastroenteritis-producing nontyphoidal Salmonella serovars, is a potent inhibitor of T-cell activation. Vi released by S. Typhi interacts with the membrane prohibitin complex and inhibits IL-2 secretion from T cells stimulated through the T-cell receptor (TCR) but does not affect PMA-activated interleukin 2 (IL-2) secretion. Treatment with Vi suppresses early activation events including TCR down-regulation, actin polymerization, and phosphorylation of ERK. Coadministration of Vi with anti-CD3 Ab reduces secretion of IL-2 and interferon γ in mice. Our findings reveal a mechanism by which S. Typhi may target T-cell immunity during establishment of typhoid."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.org/dc/terms/identifier | "doi:10.1093/infdis/jiu064"xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/author | "Dutta D."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/author | "Qadri A."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/author | "Parween F."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/author | "Santhanam S.K."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/pages | "79-88"xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/title | "The virulence polysaccharide Vi released by Salmonella Typhi targets membrane prohibitin to inhibit T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://purl.uniprot.org/core/volume | "210"xsd:string |
| http://purl.uniprot.org/citations/24470505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24470505 |
| http://purl.uniprot.org/citations/24470505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24470505 |
| http://purl.uniprot.org/uniprot/#_A8K401-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q13022-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q6QWN0-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q0GK43-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q16334-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_Q6PUJ7-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_O95974-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_P35232-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |
| http://purl.uniprot.org/uniprot/#_P60568-mappedCitation-24470505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24470505 |