| http://purl.uniprot.org/citations/24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24473437 | http://www.w3.org/2000/01/rdf-schema#comment | "Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit adipose inflammation remain unclear. Here, we used genetic and pharmacological approaches to delineate a novel role for sphingosine kinase 1 (SK1) in metabolic disorders associated with obesity. SK1 phosphorylates sphingosine to form sphingosine 1 phosphate (S1P), a bioactive sphingolipid with numerous roles in inflammation. SK1 mRNA expression was increased in adipose tissue of diet-induced obese (DIO) mice and obese type 2 diabetic humans. In DIO mice, SK1 deficiency increased markers of adipogenesis and adipose gene expression of the anti-inflammatory molecules IL-10 and adiponectin and reduced adipose tissue macrophage (ATM) recruitment and proinflammatory molecules TNFα and IL-6. These changes were associated with enhanced insulin signaling in adipose and muscle and improved systemic insulin sensitivity and glucose tolerance in SK1(-/-) mice. Specific pharmacological inhibition of SK1 in WT DIO mice also reduced adipocyte and ATM inflammation and improved overall glucose homeostasis. These data suggest that the SK1-S1P axis could be an attractive target for the development of treatments to ameliorate adipose inflammation and insulin resistance associated with obesity and type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00549.2013"xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/author | "Bielawski J."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/author | "Samad F."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/author | "Ciaraldi T.P."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/author | "Badeanlou L."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/pages | "E756-68"xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/title | "Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://purl.uniprot.org/core/volume | "306"xsd:string |
| http://purl.uniprot.org/citations/24473437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24473437 |
| http://purl.uniprot.org/citations/24473437 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24473437 |
| http://purl.uniprot.org/uniprot/#_B1AT85-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_B1AT86-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_B1AT87-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_B1AT88-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_B1AT89-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_B3KVB3-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_Q53ZR5-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_O88885-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_Q3UWJ7-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |
| http://purl.uniprot.org/uniprot/#_Q8CI15-mappedCitation-24473437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24473437 |