| http://purl.uniprot.org/citations/24474767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24474767 | http://www.w3.org/2000/01/rdf-schema#comment | "The G1 cyclins play a pivotal role in regulation of cell differentiation and proliferation. The mechanisms underlying their cell-specific roles are incompletely understood. Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of transcription factor GATA4, a key regulator of cardiomyocyte growth and differentiation. GATA4 recruits CycD2 to its target promoters, and their interaction results in synergistic activation of GATA-dependent transcription. This effect is specific to CycD2 because CycD1 is unable to potentiate activity of GATA4 and is CDK-independent. GATA4 physically interacts with CycD2 through a discreet N-terminal activation domain that is essential for the cardiogenic activity of GATA4. Human mutations in this domain that are linked to congenital heart disease interfere with CycD2-GATA4 synergy. Cardiogenesis assays in Xenopus embryos indicate that CycD2 enhances the cardiogenic function of GATA4. Together, our data uncover a role for CycD2 as a cardiogenic coactivator of GATA4 and suggest a paradigm for cell-specific effects of cyclin Ds."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1312993111"xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/author | "Nemer M."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/author | "Yamak A."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/author | "Latinkic B.V."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/author | "Dali R."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/author | "Temsah R."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/pages | "1415-1420"xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/title | "Cyclin D2 is a GATA4 cofactor in cardiogenesis."xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24474767 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24474767 |
| http://purl.uniprot.org/citations/24474767 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24474767 |
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