| http://purl.uniprot.org/citations/24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24478091 | http://www.w3.org/2000/01/rdf-schema#comment | "Pertussis toxin (PTX) is an AB5-type exotoxin produced by the bacterium Bordetella pertussis, the causative agent of whooping cough. In vivo intoxication with PTX elicits a variety of immunologic and inflammatory responses, including vasoactive amine sensitization (VAAS) to histamine (HA), serotonin (5-HT), and bradykinin (BDK). Previously, by using a forward genetic approach, we identified the HA H1 receptor (Hrh1/H1R) as the gene in mice that controls differential susceptibility to B. pertussis PTX-induced HA sensitization (Bphs). Here we show, by using inbred strains of mice, F1 hybrids, and segregating populations, that, unlike Bphs, PTX-induced 5-HT sensitivity (Bpss) and BDK sensitivity (Bpbs) are recessive traits and are separately controlled by multiple loci unlinked to 5-HT and BDK receptors, respectively. Furthermore, we found that PTX sensitizes mice to HA independently of Toll-like receptor 4, a purported receptor for PTX, and that the VAAS properties of PTX are not dependent upon endothelial caveolae or endothelial nitric oxide synthase. Finally, by using mice deficient in individual Gαi/o G-protein subunits, we demonstrate that Gαi1 and Gαi3 are the critical in vivo targets of ADP-ribosylation underlying VAAS elicited by PTX exposure."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.00971-13"xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Noubade R."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Harding B."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Teuscher C."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Diehl S.A."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Spach K."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "McElvany B."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/author | "Seeberger N."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/pages | "773-782"xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/title | "G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization."xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/24478091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24478091 |
| http://purl.uniprot.org/citations/24478091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24478091 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWA9-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXC2-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXN0-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_E9Q9X4-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWF4-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_D3Z0J2-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |
| http://purl.uniprot.org/uniprot/#_D3Z2M7-mappedCitation-24478091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24478091 |