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http://purl.uniprot.org/citations/24479710http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24479710http://www.w3.org/2000/01/rdf-schema#comment"

Aims

To address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin.

Methods and results

Fifty-four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF-1, CK7, CK20 and CDX2 using tissue microarray. The expression patterns of napsin A and TTF-1 in metastatic pulmonary adenocarcinomas were compared with matched primary lung tumours. Napsin A and TTF-1 were expressed in 87.0% and 81.5% of the metastatic pulmonary adenocarcinomas, respectively. Although there was no significant difference in the positivity of napsin A and TTF-1 as a single marker in metastatic pulmonary adenocarcinomas, the expression scores for napsin A were much higher than those for TTF-1 (P < 0.001). Moreover, the positivity and expression scores of napsin A in primary pulmonary adenocarcinomas were maintained in metastatic adenocarcinomas better than TTF-1. Most non-pulmonary adenocarcinomas were negative for napsin A, except for renal cell carcinomas (13.4%), ovarian adenocarcinomas (7.1%) and uterine endometrial adenocarcinomas (14.5%). In particular, clear cell adenocarcinomas of ovary (68.8%) and uterus (66.7%) frequently expressed napsin A.

Conclusions

These data suggest that napsin A may be a useful marker for identifying metastatic adenocarcinomas of pulmonary origin in combination with TTF-1."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.org/dc/terms/identifier"doi:10.1111/his.12383"xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Lee K."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Park S.Y."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Lee H.S."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Kim M.Y."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Moon K.C."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Kim M.A."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Kim W.H."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Koh J."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Go H."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Chung D.H."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Min H.S."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/author"Jeon Y.K."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/name"Histopathology"xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/pages"195-206"xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/title"Napsin A is a useful marker for metastatic adenocarcinomas of pulmonary origin."xsd:string
http://purl.uniprot.org/citations/24479710http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/24479710http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24479710
http://purl.uniprot.org/citations/24479710http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24479710
http://purl.uniprot.org/uniprot/#_M0QXC5-mappedCitation-24479710http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24479710
http://purl.uniprot.org/uniprot/#_O96009-mappedCitation-24479710http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24479710
http://purl.uniprot.org/uniprot/M0QXC5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24479710
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