| http://purl.uniprot.org/citations/24480479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24480479 | http://www.w3.org/2000/01/rdf-schema#comment | "Focal adhesion kinase (FAK) controls adhesion-dependent cell motility, survival, and proliferation. FAK has kinase-dependent and kinase-independent functions, both of which play major roles in embryogenesis and tumor invasiveness. The precise mechanisms of FAK activation are not known. Using x-ray crystallography, small angle x-ray scattering, and biochemical and functional analyses, we show that the key step for activation of FAK's kinase-dependent functions--autophosphorylation of tyrosine-397--requires site-specific dimerization of FAK. The dimers form via the association of the N-terminal FERM domain of FAK and are stabilized by an interaction between FERM and the C-terminal FAT domain. FAT binds to a basic motif on FERM that regulates co-activation and nuclear localization. FAK dimerization requires local enrichment, which occurs specifically at focal adhesions. Paxillin plays a dual role, by recruiting FAK to focal adhesions and by reinforcing the FAT:FERM interaction. Our results provide a structural and mechanistic framework to explain how FAK combines multiple stimuli into a site-specific function. The dimer interfaces we describe are promising targets for blocking FAK activation."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.org/dc/terms/identifier | "doi:10.1002/embj.201386399"xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Ortega A."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Walkiewicz K."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Boutterin M.C."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Arold S.T."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Girault J.A."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Gasmi L."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Arsenieva D."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Leonard P.G."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Bouceba T."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Kadare G."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Gervasi N."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Brami-Cherrier K."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/author | "Seantier B."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/pages | "356-370"xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/title | "FAK dimerization controls its kinase-dependent functions at focal adhesions."xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/24480479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24480479 |
| http://purl.uniprot.org/citations/24480479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24480479 |
| http://purl.uniprot.org/uniprot/O35346#attribution-F0A489567E8F46C3F324FDCB8B5DF3E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24480479 |
| http://purl.uniprot.org/uniprot/#_A0A0G2KAT5-mappedCitation-24480479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480479 |