| http://purl.uniprot.org/citations/24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24480844 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute coronary syndromes (ACSs) represent a high-risk condition, as enhanced platelet reactivity importantly influences myocardial perfusion and procedural results after percutaneous coronary intervention (PCI). In fact, higher rate of periprocedural myocardial infarction (PMI) and reduced event-free survival have been reported in these patients. The single nucleotide polymorphism Leu33Pro of platelet glycoprotein IIIa has been related to an increased platelet reactivity, a lower response to antiplatelet agents and higher risk of stent restenosis. Therefore, our aim was to evaluate the impact of this polymorphism on PMI in patients undergoing PCI for non-ST-segment elevation MI (NSTEMI). Our population is represented by 478 consecutive patients undergoing coronary angioplasty for NSTEMI. Cardiac biomarkers were monitored at intervals from 8 to 48 h after the procedure. Genetic analysis was performed to assess the presence of Leu33Pro polymorphism. A total of 156 patients (32.6%) were polymorphic. Clinical features did not differ according to genetic status, neither pharmacological treatment pre and during angioplasty. PlA carriers had lower rate of calcifications (P = 0.01) and higher coronary tortuosity (P = 0.03) at angiography and underwent more frequently to thrombectomy (P = 0.05). PCI-related complications did not differ according to genotype. Leu33Pro polymorphism was not associated with increased risk of periprocedural myonecrosis and PMI even after correction for baseline differences, [odds ratio (OR) (95% confidence interval (CI) = 0.70 (0.44-1.13), P = 0.15 for PMI and OR (95% CI) = 0.77 (0.53-1.11), P = 0.17 for myonecrosis, respectively]. Results were confirmed in high-risk subgroups of patients. In conclusion, among patients undergoing PCI for ACS, the polymorphism Leu33Pro of platelet glycoprotein IIIa is not associated with increased risk of PMI."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.org/dc/terms/identifier | "doi:10.1097/mbc.0b013e3283650717"xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Sinigaglia F."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "De Luca G."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Schaffer A."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Barbieri L."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Marino P."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Suryapranata H."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Verdoia M."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Cassetti E."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Secco G.G."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/author | "Perrone-Filardi P."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/name | "Blood Coagul Fibrinolysis"xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/pages | "107-113"xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/title | "Platelet PIA1/PIA2 polymorphism and the risk of periprocedural myocardial infarction in patients with acute coronary syndromes undergoing coronary angioplasty."xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/24480844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24480844 |
| http://purl.uniprot.org/citations/24480844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24480844 |
| http://purl.uniprot.org/uniprot/#_A0A5E4DMZ9-mappedCitation-24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480844 |
| http://purl.uniprot.org/uniprot/#_A0A6B9NYH9-mappedCitation-24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480844 |
| http://purl.uniprot.org/uniprot/#_A7U833-mappedCitation-24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480844 |
| http://purl.uniprot.org/uniprot/#_F1C630-mappedCitation-24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480844 |
| http://purl.uniprot.org/uniprot/#_F1C632-mappedCitation-24480844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24480844 |