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http://purl.uniprot.org/citations/24485035http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24485035http://www.w3.org/2000/01/rdf-schema#comment"

Background

Recently, it has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B-del) is associated with susceptibility to psoriasis in European and Asian populations. However, no study of this deletion has been performed in the North African population. The aim of the present study was to investigate whether this deletion is associated with familial psoriasis in Tunisian population.

Methods

A total of 34 patients and 55 healthy individuals were recruited from 7 multiplex families and a PCR assay was used to determine the association of this deletion. Its effect on susceptibility to psoriasis was assessed using the PDT program.

Results

We failed to detect any evidence of association between LCE3C_LCE3B-del and psoriasis in Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus.

Conclusions

These findings indicate that the LCE3C_LCE3B-del does not contribute in a major way to psoriasis susceptibility in Tunisian families."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.org/dc/terms/identifier"doi:10.1016/j.patbio.2013.10.003"xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Ammar M."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Doss N."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Mokni M."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Marrakchi R."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Bouhaha R."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Ben Osman A."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Ben Ammar-El Gaaied A."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Bouazizi F."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Bouchlaka-Souissi C."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Dhaoui R."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Ines Z."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/author"Soumaya K."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/name"Pathol Biol (Paris)"xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/pages"34-37"xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/title"Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families."xsd:string
http://purl.uniprot.org/citations/24485035http://purl.uniprot.org/core/volume"62"xsd:string
http://purl.uniprot.org/citations/24485035http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24485035
http://purl.uniprot.org/citations/24485035http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24485035
http://purl.uniprot.org/uniprot/#_Q5T5A8-mappedCitation-24485035http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24485035
http://purl.uniprot.org/uniprot/#_Q5TA77-mappedCitation-24485035http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24485035
http://purl.uniprot.org/uniprot/Q5T5A8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24485035
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