| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/2000/01/rdf-schema#comment | "L-2,3-diaminopropionic acid (L-Dap) is an amino acid that is a precursor of antibiotics and staphyloferrin B a siderophore produced by Staphylococcus aureus. SbnA and SbnB are encoded by the staphyloferrin B biosynthetic gene cluster and are implicated in L-Dap biosynthesis. We demonstrate here that SbnA uses PLP and substrates O-phospho-L-serine and L-glutamate to produce a metabolite N-(1-amino-1-carboxyl-2-ethyl)-glutamic acid (ACEGA). SbnB is shown to use NAD(+) to oxidatively hydrolyze ACEGA to yield α-ketoglutarate and L-Dap. Also, we describe crystal structures of SbnB in complex with NADH and ACEGA as well as with NAD(+) and α-ketoglutarate to reveal the residues required for substrate binding, oxidation, and hydrolysis. SbnA and SbnB contribute to the iron sparing response of S. aureus that enables staphyloferrin B biosynthesis in the absence of an active tricarboxylic acid cycle."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/name | "Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/name | "Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2013.12.011"xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2013.12.011"xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24485762 |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24485762 |
| http://purl.uniprot.org/citations/24485762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24485762 |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Murphy M.E."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Murphy M.E."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Heinrichs D.E."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Heinrichs D.E."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Grigg J.C."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Grigg J.C."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Rai D.K."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Rai D.K."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Takayama S.J."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Takayama S.J."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Kobylarz M.J."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/author | "Kobylarz M.J."xsd:string |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24485762 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |