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http://purl.uniprot.org/citations/24487939http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24487939http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The atrial natriuretic peptide (ANP) gene expression and some of its related single-nucleotide polymorphisms have been well established as a characterized biomarker of cardiovascular diseases. In the present study, we aimed to evaluate the potential association between one of the introduced ANP gene polymorphisms of 2238 T/C (rs5065) with coronary artery disease (CAD) in an Iranian population.

Basic methods

A total of 573 patients with CAD according to angiography reports and 293 controls without any evidence of CAD were enrolled. Allelic discrimination of the single-nucleotide polymorphism rs5065 in both groups was performed using a High Resolution Melt technique in real-time PCR analysis.

Main results

With respect to the prevalence of different genotypes of rs5065 polymorphism, the frequency of the T allele in the CAD group was significantly lower in CAD than that in the non-CAD group (59.7 vs. 65.1%, P=0.032). A significant inverse association was also found between the frequency of T allele and severity of CAD assessed by the Gensini score; the average of this score in T-allele carriers was 38.6±41.6 and that in C-allele carriers was 57.7±46.3 (P≤0.0001). Using multivariable linear regression modeling with the presence of baseline variables, the presence of the rs5065 ANP T allele could predict decreased severity of CAD assessed by the Gensini score in our population.

Principal conclusion

The presence of the rs5065 ANP polymorphism is potentially associated with a reduced risk of CAD as well as with reduced severity of CAD independent of the general risk factors of CAD."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.org/dc/terms/identifier"doi:10.1097/mca.0000000000000075"xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Boroumand M.A."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Anvari M.S."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Pourgholi L."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Ziaee S."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Sheikhvatan M."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Cheraghi S."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/author"Kalayinia S."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/name"Coron Artery Dis"xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/pages"242-246"xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/title"Association between the atrial natriuretic peptide rs5065 gene polymorphism and the presence and severity of coronary artery disease in an Iranian population."xsd:string
http://purl.uniprot.org/citations/24487939http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/24487939http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24487939
http://purl.uniprot.org/citations/24487939http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24487939
http://purl.uniprot.org/uniprot/#_B0ZBE8-mappedCitation-24487939http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24487939
http://purl.uniprot.org/uniprot/#_P01160-mappedCitation-24487939http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24487939
http://purl.uniprot.org/uniprot/P01160http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24487939
http://purl.uniprot.org/uniprot/B0ZBE8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24487939