| http://purl.uniprot.org/citations/24491562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24491562 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxysterols are oxidised forms of cholesterol or its precursors. In this study we utilised the cholesterol 24-hydroxylase knockout mouse (Cyp46a1-/-) to study the sterol and oxysterol content of brain. Despite a great reduction in the abundance of 24S-hydroxycholesterol, the dominant metabolite of cholesterol in wild type brain, no other cholesterol metabolite was found to quantitatively replace this oxysterol in the Cyp46a1-/-mouse. Only minor amounts of other side-chain oxysterols including 22R-, 24R-, 25- and (25R),26-hydroxycholesterols were detected. In line with earlier studies, levels of cholesterol were similar in Cyp46a1-/- and wild type animals. However, the level of the cholesterol precursor, desomsterol, and its parallel metabolite formed via a shut of the mevalonate pathway, 24S,25-epoxycholesterol, were reduced in the Cyp46a1-/-mouse. The reduction in abundance of 24S,25-epoxycholesterol is interesting in light of a recent report indicating that this oxysterol promotes dopaminergic neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.01.153"xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/author | "Griffiths W.J."xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/author | "Meljon A."xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/pages | "768-774"xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/title | "Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse."xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://purl.uniprot.org/core/volume | "446"xsd:string |
| http://purl.uniprot.org/citations/24491562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24491562 |
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