| http://purl.uniprot.org/citations/24493646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24493646 | http://www.w3.org/2000/01/rdf-schema#comment | "The Spt-Ada-Gcn5-acetyltransferase (SAGA) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex. Here we identified and characterized Drosophila Ataxin-7 and found that reduction of Ataxin-7 protein results in loss of components from the SAGA complex. In contrast to yeast, where loss of Ataxin-7 inactivates the deubiquitinase and results in increased H2B ubiquitination, loss of Ataxin-7 results in decreased H2B ubiquitination and H3K9 acetylation without affecting other histone marks. Interestingly, the effect on ubiquitination was conserved in human cells, suggesting a novel mechanism regulating histone deubiquitination in higher organisms. Consistent with this mechanism in vivo, we found that a recombinant deubiquitinase module is active in the absence of Ataxin-7 in vitro. When we examined the consequences of reduced Ataxin-7 in vivo, we found that flies exhibited pronounced neural and retinal degeneration, impaired movement, and early lethality."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.225151.113"xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Mohan R.D."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Workman J.L."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Abmayr S.M."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Martin-Brown S."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Weake V.M."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/author | "Dialynas G."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/pages | "259-272"xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/title | "Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration."xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/24493646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24493646 |
| http://purl.uniprot.org/citations/24493646 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24493646 |
| http://purl.uniprot.org/uniprot/Q9VYX1#attribution-938906BC34CF43A935BCA2730937A037 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24493646 |
| http://purl.uniprot.org/uniprot/Q9VVR1#attribution-938906BC34CF43A935BCA2730937A037 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24493646 |
| http://purl.uniprot.org/uniprot/Q9VVR6#attribution-938906BC34CF43A935BCA2730937A037 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24493646 |
| http://purl.uniprot.org/uniprot/Q9VQB6#attribution-430B6B066997F8C0135699D15F131BE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24493646 |
| http://purl.uniprot.org/uniprot/Q9VQB6#attribution-938906BC34CF43A935BCA2730937A037 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24493646 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFN0-mappedCitation-24493646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493646 |