| http://purl.uniprot.org/citations/24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24493819 | http://www.w3.org/2000/01/rdf-schema#comment | "Mycoplasma arthritidis-derived mitogen (MAM) is a member of the superantigen family that structurally differs from other members while still capable of initiating cognate APC/T cell interaction. In addition to the critical role of MHC class II molecules, it has been suggested that TLR2 and TLR4 may cooperate with MHC class II during MAM-induced responses. In this study, we investigated the direct involvement of TLR2 and TLR4 in MAM binding and presentation to T cells. Our results showed that MAM fails to bind to TLR2- and TLR4-transfected cells. However, coexpression of TLR2 or TLR4 with HLA-DR significantly increases MAM binding and the subsequent T cell activation compared with cells expressing HLA-DR alone. The upregulated MAM binding and activity in HLA-DR/TLR-transfected cells is abrogated by an anti-HLA-DR Ab. Interestingly, we also found that MAM complexed with soluble HLA-DR is capable of binding to both TLR2 and TLR4. The enhancing effect of TLR2 or TLR4 on MAM-induced T cell proliferation was not due to TLR ligand contamination in the MAM preparation. Taken together, these results strongly suggest that binding of MAM to HLA-DR leads to a conformational change in MAM structure allowing its interaction with TLR2 and TLR4 and a better recognition by T cells."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300591"xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Mourad W."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "El Fakhry Y."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Nadiri A."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Hassan G.S."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Shio M.T."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/author | "Shah W.A."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/pages | "2543-2550"xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/title | "Coexpression of TLR2 or TLR4 with HLA-DR potentiates the superantigenic activities of Mycoplasma arthritidis-derived mitogen."xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24493819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24493819 |
| http://purl.uniprot.org/citations/24493819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24493819 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JMH6-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L7-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |
| http://purl.uniprot.org/uniprot/#_A0A8D5XLR4-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |
| http://purl.uniprot.org/uniprot/#_A0A1V0E3V4-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |
| http://purl.uniprot.org/uniprot/#_B0UXD8-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |
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| http://purl.uniprot.org/uniprot/#_A1A435-mappedCitation-24493819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493819 |