| http://purl.uniprot.org/citations/24493833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24493833 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulated evidence shows that G protein-coupled receptor 119 (GPR119) plays a key role in glucose and lipid metabolism. Here, we explored the effect of GPR119 on cholesterol metabolism and inflammation in THP-1 macrophages and atherosclerotic plaque progression in apoE(-/-) mice. We found that oxidized LDL (Ox-LDL) significantly induced long intervening noncoding RNA (lincRNA)-DYNLRB2-2 expression, resulting in the upregulation of GPR119 and ABCA1 expression through the glucagon-like peptide 1 receptor signaling pathway. GPR119 significantly decreased cellular cholesterol content and increased apoA-I-mediated cholesterol efflux in THP-1 macrophage-derived foam cells. In vivo, apoE(-/-) mice were randomly divided into two groups and infected with lentivirus (LV)-Mock or LV-GPR119 for 8 weeks. GPR119-treated mice showed decreased liver lipid content and plasma TG, interleukin (IL)-1β, IL-6, and TNF-α levels, whereas plasma levels of apoA-I were significantly increased. Consistent with this, atherosclerotic lesion development was significantly inhibited by infection of apoE(-/-) mice with LV-GPR119. Our findings clearly indicate that, Ox-LDL significantly induced lincRNA-DYNLRB2-2 expression, which promoted ABCA1-mediated cholesterol efflux and inhibited inflammation through GPR119 in THP-1 macrophage-derived foam cells. Moreover, GPR119 decreased lipid and serum inflammatory cytokine levels, decreasing atherosclerosis in apoE(-/-) mice. These suggest that GPR119 may be a promising candidate as a therapeutic agent."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m044669"xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Wang Y.C."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Chen Z.P."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Zhao J.Y."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Hu Y.W."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Li S.F."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Gao J.J."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Qiu Y.R."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Hu Y.R."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Lu J.B."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/author | "Sha Y.H."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/pages | "681-697"xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/title | "A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/24493833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24493833 |
| http://purl.uniprot.org/citations/24493833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24493833 |
| http://purl.uniprot.org/uniprot/#_B7XCW9-mappedCitation-24493833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24493833 |