| http://purl.uniprot.org/citations/24495410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24495410 | http://www.w3.org/2000/01/rdf-schema#comment | "Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects were still unclear. In the present study, an inverse U-shaped curve was observed when treating TM4 cells with increasing doses of BPA: 1 to 10nM BPA significantly stimulated the proliferation of TM4 cells and increased the proportion of cells in S phase; >1 μM BPA caused lesser proliferation of cells. Exposure of TM4 cells to G15 or ICI 182,780, which are specific antagonists of GPR30 and estrogen receptor α/β (ERα/β), respectively, abolished BPA-induced proliferation of cells, which suggests that both GPR30 and ERα/β were involved in the observed effects of BPA. Furthermore, exposure to BPA caused rapid (5 min) activation of ERK1/2 via both GPR30 and ERα/β. Blocking the GPR30/EGFR signal transduction pathway by antagonists suppressed both phosphorylation of ERK and BPA-induced cell proliferation. BPA up-regulated mRNA and protein expression of GPR30 in a concentration-dependent manner. In summary, the results reported here indicated that activating ERK1/2 through GPR30 and ERα/β is involved in low doses of BPA that promoted growth of Sertoli TM4 cells. The GPR30/EGFR/ERK signal is the downstream transduction pathway in BPA-induced proliferation of TM4 Sertoli cells."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxlet.2014.01.035"xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Liu H.Y."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Zhang K.S."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Wong C.K."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Huang H.B."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Wang H.S."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Giesy J.P."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/author | "Ge L.C."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/name | "Toxicol Lett"xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/pages | "81-89"xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/title | "Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor alpha/beta in low doses of bisphenol A promoting growth of Sertoli TM4 cells."xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://purl.uniprot.org/core/volume | "226"xsd:string |
| http://purl.uniprot.org/citations/24495410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24495410 |
| http://purl.uniprot.org/citations/24495410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24495410 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Y6-mappedCitation-24495410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24495410 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-24495410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24495410 |
| http://purl.uniprot.org/uniprot/#_A0A1W7GYY3-mappedCitation-24495410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24495410 |
| http://purl.uniprot.org/uniprot/#_A0A1W7GYY4-mappedCitation-24495410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24495410 |