| http://purl.uniprot.org/citations/24497644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24497644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24497644 | http://www.w3.org/2000/01/rdf-schema#comment | "Atherosclerosis is associated with chronic inflammation occurring over decades. The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in large atherosclerotic plaques, and its activity has been linked to the progression of macrophages to the lipid-laden foam cells present in atherosclerotic plaques. We report here the crystal structure of human 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain. The loop is flanked by two Ca(2+)-binding sites that confer Ca(2+)-dependent membrane binding. A comparison of the human 15-LOX-2 and 5-LOX structures reveals similarities at the active sites, as well striking differences that can be exploited for design of isoform-selective inhibitors."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.543777"xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.543777"xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Neau D.B."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Neau D.B."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Newcomer M.E."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Newcomer M.E."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Bartlett S.G."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Bartlett S.G."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Kobe M.J."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Kobe M.J."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Mitchell C.E."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/author | "Mitchell C.E."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/pages | "8562-8569"xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/pages | "8562-8569"xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/title | "The structure of human 15-lipoxygenase-2 with a substrate mimic."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/title | "The structure of human 15-lipoxygenase-2 with a substrate mimic."xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24497644 | http://purl.uniprot.org/core/volume | "289"xsd:string |