| http://purl.uniprot.org/citations/24501251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24501251 | http://www.w3.org/2000/01/rdf-schema#comment | "In S. cerevisiae, the 5'-3' exonuclease Rat1p partakes in transcription termination. Although Rat1p-mediated RNA degradation has been suggested to play a role for this activity, the exact mechanisms by which Rat1p helps release RNA polymerase II (RNAPII) from the DNA template are poorly understood. Here we describe a function of Rat1p in regulating phosphorylation levels of the C-terminal domain (CTD) of the largest RNAPII subunit, Rpb1p, during transcription elongation. The rat1-1 mutant exhibits highly elevated levels of CTD phosphorylation as well as RNAPII distribution and transcription termination defects. These phenotypes are all rescued by overexpression of the CTD phosphatase Fcp1p, suggesting a functional relationship between the absence of Rat1p activity, elevated CTD phosphorylation, and transcription defects. We also demonstrate that rat1-1 cells display increased RNAPII transcription kinetics, a feature that may contribute to the cellular phenotypes of the mutant. Consistently, the rat1-1 allele is synthetic lethal with the rpb1-E1103G mutation, causing increased RNAPII speed, and is suppressed by the rpb2-10 mutation, causing slowed transcription. Thus, Rat1p plays more complex roles in controlling transcription than previously thought."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.041129.113"xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/author | "Schmid M."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/author | "Jensen T.H."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/author | "Malagon F."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/author | "Jimeno-Gonzalez S."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/author | "Haaning L.L."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/pages | "551-558"xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/title | "Rat1p maintains RNA polymerase II CTD phosphorylation balance."xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/24501251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24501251 |
| http://purl.uniprot.org/citations/24501251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24501251 |
| http://purl.uniprot.org/uniprot/Q02792#attribution-F06261FEFA154A4586B1FB8F0CFB6B3E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/#_Q03254-mappedCitation-24501251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/#_P04050-mappedCitation-24501251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/#_Q02792-mappedCitation-24501251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/Q02792 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/Q03254 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24501251 |
| http://purl.uniprot.org/uniprot/P04050 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24501251 |