| http://purl.uniprot.org/citations/24503275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24503275 | http://www.w3.org/2000/01/rdf-schema#comment | "Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is a neurodegenerative tauopathy caused by mutations in the tau gene (MAPT). Individuals with FTDP-17 have deficits in learning, memory, and language, in addition to personality and behavioral changes that are often characterized by a lack of social inhibition. Several transgenic mouse models expressing tau mutations have been tested extensively for memory or motor impairments, though reports of amygdala-dependent behaviors are lacking. To this end, we tested the rTg4510 mouse model on a behavioral battery that included amygdala-dependent tasks of exploration. As expected, rTg4510 mice exhibit profound impairments in hippocampal-dependent learning and memory tests, including contextual fear conditioning. However, rTg4510 mice also display an abnormal hyperexploratory phenotype in the open-field assay, elevated plus maze, light-dark exploration, and cued fear conditioning, indicative of amygdala dysfunction. Furthermore, significant tau burden is detected in the amygdala of both rTg4510 mice and human FTDP-17 patients, suggesting that the rTg4510 mouse model recapitulates the behavioral disturbances and neurodegeneration of the amygdala characteristic of FTDP-17."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2013.12.023"xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Tong J."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Dickson D.W."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Cook C."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Fryer J.D."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Kurti A."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Petrucelli L."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Murray M.E."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Castanedes-Casey M."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Phillips V."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Rousseau L."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Dunmore J.H."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Scheffel K."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Penuliar M.S."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/author | "Shukoor N."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/pages | "1769-1777"xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/title | "Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia."xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/24503275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24503275 |
| http://purl.uniprot.org/citations/24503275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24503275 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J063-mappedCitation-24503275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24503275 |