| http://purl.uniprot.org/citations/24509249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24509249 | http://www.w3.org/2000/01/rdf-schema#comment | "Piwi-like gene family members (Piwil 1-4) are considered stem cell-associated genes/proteins. These are expressed predominantly in germline cells, but are re-expressed in different tumors. Piwil 1-4 gene expression has not previously been studied and correlated with clinicopathological parameters in renal cell carcinomas (RCC). The Piwil 1-4 transcript levels were analyzed by quantitative real-time PCR in 73 clear cell RCC (ccRCC) tissues and corresponding normal tissues. The transcript levels of Piwil 1, 2 and 4 were strongly and significantly correlated with each other, in both the tumor tissues and the normal tissues (P<0.001; Spearman's rank test). Piwil 4 gene expression was significantly higher in the ccRCC tissues than that in the corresponding normal renal tissues (P<0.001; Wilcoxon signed-rank test). When the ccRCC patient cohort was divided according to the median Piwil 1-4 expression into low- and high-expression groups and according to age into younger (≤64years) and older patient groups (>64years), the younger patients displayed significantly higher levels of Piwil 1 mRNA in comparison to the older patients (P=0.010; Fisher's exact test). Interestingly, Piwil 1 expression was left-right polarized in the normal tissues but not in the tumor tissues (P=0.004; Fisher's exact test). Altogether, associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis as well as in renal tissue embryology."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2014.01.014"xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Hartmann A."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Taubert H."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Greither T."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Schick S."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Weigelt K."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Nolte E."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Wullich B."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Wach S."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Rau T.T."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Al-Janabi O."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Legal W."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/author | "Stohr C."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/pages | "686-690"xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/title | "Piwi-like 1 and 4 gene transcript levels are associated with clinicopathological parameters in renal cell carcinomas."xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://purl.uniprot.org/core/volume | "1842"xsd:string |
| http://purl.uniprot.org/citations/24509249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24509249 |
| http://purl.uniprot.org/citations/24509249 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24509249 |
| http://purl.uniprot.org/uniprot/#_A0A140VKG8-mappedCitation-24509249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24509249 |
| http://purl.uniprot.org/uniprot/#_Q7Z3Z4-mappedCitation-24509249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24509249 |
| http://purl.uniprot.org/uniprot/#_Q96J94-mappedCitation-24509249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24509249 |