| http://purl.uniprot.org/citations/24510316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24510316 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with inflammatory bowel diseases often develop colon carcinoma. Combined treatment of azoxymethane (AOM) and dextran sulfate sodium (DSS) recapitulates colitis-associated cancer in mice. AOM/DSS-induced tumor formation was reduced in CCL3- or its specific receptor, CCR5-deficient mice despite the presence of a massive infiltration of inflammatory cells. However, AOM/DSS-induced type I collagen-positive fibroblast accumulation in the colon was reduced in CCL3- or CCR5-deficient mice. This was associated with depressed expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF), which is expressed mainly by fibroblasts. Moreover in vitro, CCL3 induced fibroblasts to proliferate and to enhance HB-EGF expression. Furthermore, CCR5 blockade reduced tumor formation together with reduced fibroblast accumulation and HB-EGF expression, even when administered after the development of multiple colon tumors. Thus, CCL3-CCR5-mediated fibroblast accumulation may be required, in addition to leukocyte infiltration, to induce full-blown colitis-associated carcinogenesis. Our studies shed light on a therapeutic potential of CCR5 antagonist for patients with colitis-associated cancer."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.28779"xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/author | "Baba T."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/author | "Sasaki S."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/author | "Shinagawa K."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/author | "Mukaida N."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/pages | "1297-1306"xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/title | "Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/24510316 | http://purl.uniprot.org/core/volume | "135"xsd:string |
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