| http://purl.uniprot.org/citations/24510904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24510904 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1318306111"xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Ding J."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Huber H."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Deloukas P."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Lopez G."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Hunt S.E."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Martinez M."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Longo D.L."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Morris H.R."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Langford C."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Potter S."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Saad M."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Smith C."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Riess O."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Scheffer H."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Walker R."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "Johnson R."xsd:string |
| http://purl.uniprot.org/citations/24510904 | http://purl.uniprot.org/core/author | "O'Brien R."xsd:string |