| http://purl.uniprot.org/citations/24515439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24515439 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite playing a central role in tolerance, little is known regarding the mechanism by which intracellular CTLA-4 is shuttled from the trans-Golgi network to the surfaces of T cells. In this context, Ras-related GTPase Rab8 plays an important role in the intracellular transport, while we have previously shown that CTLA-4 binds to the immune cell adaptor TRIM in T cells. In this study, we demonstrate that CTLA-4 forms a multimeric complex comprised of TRIM and related LAX that in turn binds to GTP bound Rab8 for post-Golgi transport to the cell surface. LAX bound via its N terminus to active GTP-Rab8, as well as the cytoplasmic tail of CTLA-4. TRIM required LAX for binding to Rab8 in a complex. Wild-type LAX or its N terminus (residues 1 to 77) increased CTLA-4 surface expression, whereas small interfering RNAs of Rab8 or LAX or disruption of LAX/Rab8 binding reduced numbers of CTLA-4-containing vesicles and its coreceptor surface expression. LAX also promoted the polarization of CTLA-4 and the reorientation of the microtubule-organizing center to the site of T-cell receptor engagement. Our results identify a novel CTLA-4/TRIM/LAX/Rab8 effector complex in the transport of CTLA-4 to the surfaces of T cells."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01331-13"xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/author | "Schneider H."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/author | "Valk E."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/author | "Banton M.C."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/author | "Inder K.L."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/pages | "1486-1499"xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/title | "Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression."xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24515439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24515439 |
| http://purl.uniprot.org/citations/24515439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24515439 |
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