| http://purl.uniprot.org/citations/24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24516201 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the cellular dynamics of Aire-expressing lineage(s) among medullary thymic epithelial cells (AEL-mTECs) is essential for gaining insight into the roles of Aire in establishment of self-tolerance. In this study, we monitored the maturation program of AEL-mTECs by temporal lineage tracing, in which bacterial artificial chromosome transgenic mice expressing tamoxifen-inducible Cre recombinase under control of the Aire regulatory element were crossed with reporter strains. We estimated that the half-life of AEL-mTECs subsequent to Aire expression was ∼7-8 d, which was much longer than that reported previously, owing to the existence of a post-Aire stage. We found that loss of Aire did not alter the overall lifespan of AEL-mTECs, inconsistent with the previous notion that Aire expression in medullary thymic epithelial cells (mTECs) might result in their apoptosis for efficient cross-presentation of self-antigens expressed by AEL-mTECs. In contrast, Aire was required for the full maturation program of AEL-mTECs, as exemplified by the lack of physiological downregulation of CD80 during the post-Aire stage in Aire-deficient mice, thus accounting for the abnormally increased CD80(high) mTECs seen in such mice. Of interest, increased CD80(high) mTECs in Aire-deficient mice were not mTEC autonomous and were dependent on cross-talk with thymocytes. These results further support the roles of Aire in the differentiation program of AEL-mTECs."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1302786"xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Nishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Mouri Y."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Nishijima H."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Matsumoto M.'"xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Morimoto J."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Fehling H.J."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Hirota F."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/author | "Luche H."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/pages | "2585-2592"xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/title | "Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program."xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24516201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24516201 |
| http://purl.uniprot.org/citations/24516201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24516201 |
| http://purl.uniprot.org/uniprot/#_B2MVU6-mappedCitation-24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24516201 |
| http://purl.uniprot.org/uniprot/#_D6RDQ5-mappedCitation-24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24516201 |
| http://purl.uniprot.org/uniprot/#_E9Q441-mappedCitation-24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24516201 |
| http://purl.uniprot.org/uniprot/#_Q3ZB65-mappedCitation-24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24516201 |
| http://purl.uniprot.org/uniprot/#_Q3ZB71-mappedCitation-24516201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24516201 |