| http://purl.uniprot.org/citations/24520353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24520353 | http://www.w3.org/2000/01/rdf-schema#comment | "Related Transcriptional Enhancer Factor-1 (RTEF-1) has been suggested to induce angiogenesis through regulating target genes. Whether RTEF-1 has a direct role in angiogenesis and what specific genes are involved in RTEF-1 driven angiogenisis have not been elucidated. We found that over-expressing RTEF-1 in Human dermal microvascular endothelial cells-1 (HMEC-1) significantly increased endothelial cell aggregation, growth and migration while the processes were inhibited by siRNA of RTEF-1. In addition, we observed that Endothelial differentiation gene-1 (Edg-1) expression was up-regulated by RTEF-1 at the transcriptional level. RTEF-1 could bind to Edg-1 promoter and subsequently induce its activity. Edg-1 siRNA significantly blocked RTEF-1-driven increases in endothelial cell aggregation in a Matrigel assay and retarded RTEF-1-induced endothelial cell growth and migration. Pertussis Toxin (PTX), a Gi/Go protein sensitive inhibitor, was found to inhibit RTEF-1 driven endothelial cell aggregation and migration. Our data demonstrates that Edg-1 is a potential target gene of RTEF-1 and is involved in RTEF-1-induced angiogenesis in endothelial cells. Gi/Go protein coupled receptor pathway plays a role in RTEF-1 driven angiogenesis in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0088143"xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "He P."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "An X."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "Messmer-Blust A.F."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/author | "Philbrick M.J."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/pages | "e88143"xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/title | "Endothelial differentiation gene-1, a new downstream gene is involved in RTEF-1 induced angiogenesis in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/24520353 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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