| http://purl.uniprot.org/citations/24520415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24520415 | http://www.w3.org/2000/01/rdf-schema#comment | "ApoA-II is the second most abundant protein on HDL making up ∼ 20% of the total protein but its functions have still only been partially characterized. Recent methodological improvements have allowed for the recombinant expression and characterization of human apoA-II which shares only 55% sequence homology with murine apoA-II. Here we describe the purification of the two most common polymorphic variants of apoA-II found in inbred mouse strains, differing at 3 amino acid sites. C57BL/6 mice having variant apoA-II(a) have lower plasma HDL levels than FVB/N mice that have variant apoA-II(b). Characterization of the helical structure of these two variants reveals a more alpha-helical structure for the FVB/N apoA-II. These changes do not alter the lipid or HDL binding of the two apoA-II variants, but significantly increase the ability of the FVB/N variant to promote both ABCA1 and ABCG1 mediated cellular cholesterol efflux. These differences may be differentially altering plasma HDL apoA-II levels. In vivo, neither C57 nor FVB apoA-II protein levels are affected by the absence of apoE, while an apoE/apoA-I double deficiency results in a 50% decrease of plasma FVB apoA-II but results in undetectable levels of C57 apoA-II in the plasma. FVB apoA-II is able to form an HDL particle in the absence of apoE or apoA-I."xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0088705"xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/author | "Reardon C.A."xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/author | "Sontag T.J."xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/pages | "e88705"xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/title | "Polymorphisms of mouse apolipoprotein A-II alter its physical and functional nature."xsd:string |
| http://purl.uniprot.org/citations/24520415 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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| http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-24520415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24520415 |
| http://purl.uniprot.org/uniprot/#_G3UWW2-mappedCitation-24520415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24520415 |
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| http://purl.uniprot.org/uniprot/#_Q58EV2-mappedCitation-24520415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24520415 |