| http://purl.uniprot.org/citations/24525234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24525234 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange factor GEF-H1 plays a critical role in a positive feedback loop for the RAS/MAPK pathway independent of its RhoGEF activity. GEF-H1 acts as an adaptor protein linking the PP2A B' subunits to KSR-1, thereby mediating the dephosphorylation of KSR-1 S392 and activation of MAPK signaling. GEF-H1 is important for the growth and survival of HRAS(V12)-transformed cells and pancreatic tumor xenografts. GEF-H1 expression is induced by oncogenic RAS and is correlated with pancreatic neoplastic progression. Our results, therefore, identify GEF-H1 as an amplifier of MAPK signaling and provide mechanistic insight into the progression of RAS mutant tumors."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2014.01.025"xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Ikura M."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Moffat J."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Marshall C.B."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Ketela T."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Rottapel R."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Larose J."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Meiri D."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Tsao M.S."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Sandi M.J."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Medrano M."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Kent O.A."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Cullis J."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Normand J."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Marcotte R."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Radulovich N."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/author | "Mokady D."xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/pages | "181-195"xsd:string |
| http://purl.uniprot.org/citations/24525234 | http://purl.uniprot.org/core/title | "The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1."xsd:string |