| http://purl.uniprot.org/citations/24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24531553 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence indicates that the pathogenesis of neuropathic pain is mediated through spinal cord microglia activation. The intracellular protease caspase-6 (CASP6) is known to regulate neuronal apoptosis and axonal degeneration; however, the contribution of microglia and CASP6 in modulating synaptic transmission and pain is unclear. Here, we found that CASP6 is expressed specifically in C-fiber axonal terminals in the superficial spinal cord dorsal horn. Animals exposed to intraplantar formalin or bradykinin injection exhibited CASP6 activation in the dorsal horn. Casp6-null mice had normal baseline pain, but impaired inflammatory pain responses. Furthermore, formalin-induced second-phase pain was suppressed by spinal injection of CASP6 inhibitor or CASP6-neutralizing antibody, as well as perisciatic nerve injection of CASP6 siRNA. Recombinant CASP6 (rCASP6) induced marked TNF-α release in microglial cultures, and most microglia within the spinal cord expressed Tnfa. Spinal injection of rCASP6 elicited TNF-α production and microglia-dependent pain hypersensitivity. Evaluation of excitatory postsynaptic currents (EPSCs) revealed that rCASP6 rapidly increased synaptic transmission in spinal cord slices via TNF-α release. Interestingly, the microglial inhibitor minocycline suppressed rCASP6 but not TNF-α-induced synaptic potentiation. Finally, rCASP6-activated microglial culture medium increased EPSCs in spinal cord slices via TNF-α. Together, these data suggest that CASP6 released from axonal terminals regulates microglial TNF-α secretion, synaptic plasticity, and inflammatory pain."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci72230"xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Lu N."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Liu Y.C."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Ji R.R."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Xu Z.Z."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Park C.K."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Berta T."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/author | "Xie R.G."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/pages | "1173-1186"xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/title | "Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion."xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/24531553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24531553 |
| http://purl.uniprot.org/citations/24531553 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24531553 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_D6RG55-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_F6R6K0-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |
| http://purl.uniprot.org/uniprot/#_Q62327-mappedCitation-24531553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24531553 |