| http://purl.uniprot.org/citations/24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24532689 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mre11 complex (Mre11, Rad50, and Nbs1) is a central component of the DNA damage response (DDR), governing both double-strand break repair and DDR signaling. Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain. Mutations that inactivate the hook domain produce a null phenotype. In this study, we analyzed mutants with reduced hook domain function in an effort to stratify hook-dependent Mre11 complex functions. One of these alleles, Rad50(46), conferred reduced Zn(2+) affinity and dimerization efficiency. Homozygous Rad50(46/46) mutations were lethal in mice. However, in the presence of wild-type Rad50, Rad50(46) exerted a dominant gain-of-function phenotype associated with chronic DDR signaling. At the organismal level, Rad50(+/46) exhibited hydrocephalus, liver tumorigenesis, and defects in primitive hematopoietic and gametogenic cells. These outcomes were dependent on ATM, as all phenotypes were mitigated in Rad50(+/46) Atm(+/-) mice. These data reveal that the murine Rad50 hook domain strongly influences Mre11 complex-dependent DDR signaling, tissue homeostasis, and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.236745.113"xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Tainer J.A."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Keeney S."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Lange J."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Petrini J.H."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Inagaki A."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Roset R."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Hohl M."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Lafrance-Vanasse J."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Scandura J.M."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/author | "Brenet F."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/pages | "451-462"xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/title | "The Rad50 hook domain regulates DNA damage signaling and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/24532689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24532689 |
| http://purl.uniprot.org/citations/24532689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24532689 |
| http://purl.uniprot.org/uniprot/#_D3Z0Q2-mappedCitation-24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24532689 |
| http://purl.uniprot.org/uniprot/#_E9PUJ2-mappedCitation-24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24532689 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGB5-mappedCitation-24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24532689 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGX3-mappedCitation-24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24532689 |
| http://purl.uniprot.org/uniprot/#_A8Y5I3-mappedCitation-24532689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24532689 |