| http://purl.uniprot.org/citations/24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24553291 | http://www.w3.org/2000/01/rdf-schema#comment | "Axon guidance by commissural neurons has been well documented, providing us with a molecular logic of how midline crossing is achieved during development. Despite these advances, knowledge of the intrinsic genetic programs is still limited and it remains obscure whether the expression of a single transcription factor is sufficient to activate transcriptional programs that ultimately enable midline crossing. Here, we show in the mouse that the homeodomain transcription factor Dbx1 is expressed by a subset of progenitor cells that give rise to commissural neurons in the dorsal midbrain. Gain- and loss-of-function analyses indicate that the expression of Dbx1 alone is sufficient and necessary to trigger midline crossing in vivo. We also show that Robo3 controls midline crossing as a crucial downstream effector of the Dbx1-activated molecular programs. Furthermore, Dbx1 suppresses the expression of the transcriptional program for ipsilateral neuron differentiation in parallel. These results suggest that a single transcription factor, Dbx1, has an essential function in assigning midline-crossing identity, thereby contributing crucially to the establishment of the wiring laterality in the developing nervous system."xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.102327"xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/author | "Shirasaki R."xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/author | "Inamata Y."xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/pages | "1260-1271"xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/title | "Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons."xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/24553291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24553291 |
| http://purl.uniprot.org/citations/24553291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY42-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQK9-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_P52950-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_P70660-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A338P6F7-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0A338P6U2-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_A0JNS7-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_E9QPQ1-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_E9PVX6-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_F6R8N2-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |
| http://purl.uniprot.org/uniprot/#_F6SM03-mappedCitation-24553291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24553291 |