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| http://purl.uniprot.org/citations/24554727 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms by which aging leads to alterations in brain structure and cognitive deficits are unclear. Α deficient cholinergic system has been implicated as one of the main factors that could confer a heightened vulnerability to the aging process, and mice lacking high-affinity nicotinic receptors (β2(-/-)) have been proposed as an animal model of accelerated cognitive aging. To date, however, age-related changes in neuronal microanatomy have not been studied in these mice. In the present study, we examine the neuronal structure of yellow fluorescent protein (YFP(+)) layer V neurons in 2 cytoarchitectonically distinct cortical regions in wild-type (WT) and β2(-/-) animals. We find that (1) substantial morphological differences exist between YFP(+) cells of the anterior cingulate cortex (ACC) and primary visual cortex (V1), in both genotypes; (2) in WT animals, ACC cells are more susceptible to aging compared with cells in V1; and (3) β2 deletion is associated with a regionally and temporally specific increase in vulnerability to aging. ACC cells exhibit a prematurely aged phenotype already at 4-6 months, whereas V1 cells are spared in adulthood but strongly affected in old animals. Collectively, our data reveal region-specific synergistic effects of aging and genotype and suggest distinct vulnerabilities in V1 and ACC neurons."xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhu019"xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/author | "Konsolaki E."xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/author | "Skaliora I."xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/pages | "2138-2148"xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/title | "Premature Aging Phenotype in Mice Lacking High-Affinity Nicotinic Receptors: Region-Specific Changes in Layer V Pyramidal Cell Morphology."xsd:string |
| http://purl.uniprot.org/citations/24554727 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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