| http://purl.uniprot.org/citations/24561039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24561039 | http://www.w3.org/2000/01/rdf-schema#comment | "During interphase, Rab11-GTPase-containing endosomes recycle endocytic cargo. However, little is known about Rab11 endosomes in mitosis. Here, we show that Rab11 localizes to the mitotic spindle and regulates dynein-dependent endosome localization at poles. We found that mitotic recycling endosomes bind γ-TuRC components and associate with tubulin in vitro. Rab11 depletion or dominant-negative Rab11 expression disrupts astral microtubules, delays mitosis, and redistributes spindle pole proteins. Reciprocally, constitutively active Rab11 increases astral microtubules, restores γ-tubulin spindle pole localization, and generates robust spindles. This suggests a role for Rab11 activity in spindle pole maturation during mitosis. Rab11 depletion causes misorientation of the mitotic spindle and the plane of cell division. These findings suggest a molecular mechanism for the organization of astral microtubules and the mitotic spindle through Rab11-dependent control of spindle pole assembly and function. We propose that Rab11 and its associated endosomes cocontribute to these processes through retrograde transport to poles by dynein."xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2014.01.014"xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/author | "Hehnly H."xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/author | "Doxsey S."xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/pages | "497-507"xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/title | "Rab11 endosomes contribute to mitotic spindle organization and orientation."xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/24561039 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24561039 |
| http://purl.uniprot.org/citations/24561039 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24561039 |
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| http://purl.uniprot.org/uniprot/O14576#attribution-210E724BB2A8ED52E3026A13E539DDA2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24561039 |
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