| http://purl.uniprot.org/citations/24565998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24565998 | http://www.w3.org/2000/01/rdf-schema#comment | "The Periostin Cre (Postn-Cre) lineage includes endocardial and neural crest derived mesenchymal cells of the cardiac cushions, neural crest-derived components of the sympathetic and enteric nervous systems, and cardiac fibroblasts. In this study, we use the Postn-Cre transgenic allele to conditionally ablate Hand2 (H2CKO). We find that Postn-Cre H2CKOs die shortly after birth despite a lack of obvious cardiac structural defects. To ascertain the cause of death, we performed a detailed comparison of the Postn-Cre lineage and Hand2 expression at mid and late stages of embryonic development. Gene expression analyses demonstrate that Postn-Cre ablates Hand2 from the adrenal medulla as well as the sphenopalatine ganglia of the head. In both cases, Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh), a gene encoding a crucial catecholaminergic biosynthetic enzyme. Expression of the genes Tyrosine Hydroxylase (Th) and Phenylethanolamine N-methyltransferase (Pnmt), which also encode essential catecholaminergic enzymes, were severely reduced in postnatal adrenal glands. Electrocardiograms demonstrate that 3-day postnatal Postn-Cre H2CKO pups exhibit sinus bradycardia. In conjunction with the aforementioned gene expression analyses, these results strongly suggest that the observed postnatal lethality occurs due to a catecholamine deficiency and subsequent heart failure."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2014.02.010"xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "Howard M.J."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "Rubart M."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "Firulli A.B."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "Firulli B.A."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "Vincentz J.W."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/author | "VanDusen N.J."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/pages | "149-158"xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/title | "Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death."xsd:string |
| http://purl.uniprot.org/citations/24565998 | http://purl.uniprot.org/core/volume | "388"xsd:string |
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