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http://purl.uniprot.org/citations/24566094http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24566094http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To identify protective human leukocyte antigen (HLA) alleles in an HIV-infected south-east Asian population, in whom HLA-B*57 prevalence is lower than other ethnic groups, and HIV-1 CRF01_AE is the dominant circulating subtype.

Design

Cross-sectional study of Thai patients with chronic HIV infection.

Methods

Five hundred and fifty-seven HIV-1 CRF01_AE-infected Thais were recruited. Their HLA type and viral load were determined to statistically analyze the association of each allele in viral control. In-silico molecular dynamics was also used to evaluate the effect of HLA structure variants on epitope binding.

Results

HLA-B*35:05 was identified as the most protective allele (P=0.003, q=0.17), along with HLA-B*57:01 (P=0.044, q=0.31). Structurally, HLA-B*35:05 belonged to the HLA-B*35-PY group of HLA-B*35 alleles; however, unlike the other HLA-B*35 alleles that carry Arg (R) at residue 97, it has unique sequences at T94, L95, and S97, located within the peptide-binding groove. Analysis of the three-dimensional HLA structure and molecular dynamics indicates that S97 in HLA-B*35:05 leads to less flexibility in the groove, and shorter distances between the α-helixes compared with the disease-susceptible HLA-B*35-PY allele, HLA-B*35:01.

Conclusion

These data indicate the existence of a protective effect of HLA-B*57 across ethnic groups and highlight HLA-B*35:05 as an allele uniquely protective in subtype CRF01_AE-infected Thais. The divergence of HLA-B*35:05 from conventional HLA-B*35-PY structural sequences at the peptide-binding groove is consistent with previous studies that have identified HLA residue 97 as strongly influential in shaping HLA impact on immune control of HIV, and that a more restricted peptide-binding motif may be associated with improved control."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.org/dc/terms/identifier"doi:10.1097/qad.0000000000000206"xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Miura T."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Mori M."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Yasunami M."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Miyahara R."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Maekawa T."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Goulder P."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Ariyoshi K."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Sawanpanyalert P."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Pathipvanich P."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Wichukchinda N."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/author"Rojanawiwat A."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/name"AIDS"xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/pages"959-967"xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/title"HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low."xsd:string
http://purl.uniprot.org/citations/24566094http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/24566094http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24566094
http://purl.uniprot.org/citations/24566094http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24566094
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-24566094http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24566094
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-24566094http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24566094
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http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-24566094http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24566094
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