| http://purl.uniprot.org/citations/2456920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2456920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2456920 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein kinase domains of v-kit, the oncogene of the acute transforming feline retrovirus HZ4-FeSV (HZ4-feline sarcoma virus), CSF-1R (macrophage colony stimulating factor receptor) and PDGFR (platelet derived growth factor receptor) display extensive homology. Because of the close structural relationship of v-kit, CSF-1R and PDGFR we predicted that c-kit would encode a protein kinase transmembrane receptor (Besmer et al., 1986a; Yarden et al., 1986). We have now determined the primary structure of murine c-kit from a DNA clone isolated from a brain cDNA library. The nucleotide sequence of the c-kit cDNA predicts a 975 amino acid protein product with a calculated mol. wt of 109.001 kd. It contains an N-terminal signal peptide, a transmembrane domain (residues 519-543) and in the C-terminal half the v-kit homologous sequences (residues 558-925). c-kit therefore contains the features which are characteristic of a transmembrane receptor kinase. Comparison of c-kit, CSF-1R and PDGFR revealed a unique structural relationship of these receptor kinases suggesting a common evolutionary origin. The outer cellular domain of c-kit was shown to be related to the immunoglobulin superfamily. The sites of expression of c-kit in normal tissue predict a function in the brain and in hematopoietic cells. N-terminal sequences which include the extracellular domain and the transmembrane domain as well as 50 amino acids from the C-terminus of c-kit are deleted in v-kit. These structural alterations are likely determinants of the oncogenic activation of v-kit.(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1988.tb02907.x"xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1988.tb02907.x"xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Besmer P."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Besmer P."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Ruddle F.H."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Ruddle F.H."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Ray P."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Ray P."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Jhanwar S."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Jhanwar S."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Qiu F."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Qiu F."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Barker P.E."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/author | "Barker P.E."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/pages | "1003-1011"xsd:string |
| http://purl.uniprot.org/citations/2456920 | http://purl.uniprot.org/core/pages | "1003-1011"xsd:string |