| http://purl.uniprot.org/citations/24576427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24576427 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell retaining stem cell identity and the other cell destined to differentiate. These cell fates are established by cell-type-specific genetic networks. To comprehensively identify components of these networks, we performed a large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering ∼25% of the genome. The screen identified 366 genes that affect GSC maintenance, differentiation, or other processes involved in oogenesis. Comparison of GSC regulators with neural stem cell self-renewal factors identifies common and cell-type-specific self-renewal genes. Importantly, we identify the histone methyltransferase Set1 as a GSC-specific self-renewal factor. Loss of Set1 in neural stem cells does not affect cell fate decisions, suggesting a differential requirement of H3K4me3 in different stem cell lineages. Altogether, our study provides a resource that will help to further dissect the networks underlying stem cell self-renewal."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2014.01.020"xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Kelley C."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Xie T."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Yan D."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Perkins L.A."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Cooley L."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Binari R."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Ayers K."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Yang-Zhou D."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Neumuller R.A."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Vinayagam A."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Buckner M."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/author | "Randklev S."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/pages | "459-473"xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/title | "A regulatory network of Drosophila germline stem cell self-renewal."xsd:string |
| http://purl.uniprot.org/citations/24576427 | http://purl.uniprot.org/core/volume | "28"xsd:string |