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http://purl.uniprot.org/citations/24576533http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24576533http://www.w3.org/2000/01/rdf-schema#comment"Pleckstrin homology domain (PH domain) comprises approximately 120 amino acids and is integrated in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. This domain can bind phosphatidylinositol (3,4,5)-triphosphate and phosphatidylinositol (4,5)-biphosphate and proteins such as the βγ-subunits of heterotrimeric G proteins and protein kinase C. Associations with psychiatric diseases have not been investigated yet. To identify genes involved in response to antipsychotics, mice were treated with haloperidol (1mg/kg, n = 11) or saline (n = 12) for one week. By analyzing microarray data, we observed an increase of pleckstrin homology domain containing 6 (PLEKHA6) gene expression. Furthermore, we genotyped 263 schizophrenic patients, who were treated monotherapeutically with different antipsychotics within randomized-controlled trials. Psychopathology was measured weekly using the PANSS for a minimum of four and a maximum of twelve weeks. Correlations between PANSS subscale scores at baseline and PANSS improvement scores after four weeks of treatment and genotypes were calculated by using a linear model for all investigated SNPs. We found associations between four PLEKHA6 polymorphisms (rs17333933 (T/G), rs3126209 (C/T), rs4951338 (A/G) and rs100900571 (T/C)) and different PANSS subscales at baseline. Furthermore two different polymorphisms (rs7513240 (T/C), rs4951353 (A/G)) were found to be associated with therapy response in terms of a significant correlation with different PANSS improvement subscores after four weeks of antipsychotic treatment. Our observation of an association between genetic polymorphisms of a protein of the PH domain and psychopathology data in schizophrenic patients might be indicative for an involvement of PLEKHA6 in the pathophysiology of schizophrenia and the therapy response towards antipsychotics."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.org/dc/terms/identifier"doi:10.1016/j.pnpbp.2014.02.006"xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Muller N."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Giegling I."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Rujescu D."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Zill P."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Moller H.J."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Schafer M."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Hartmann A.M."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Riedel M."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Genius J."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Dehning S."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Spellmann I."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Musil R."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Cerovecki A."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Meyerwas S."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Schennach R."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/author"Seemuller F."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/name"Prog Neuropsychopharmacol Biol Psychiatry"xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/pages"190-195"xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/title"Pleckstrin homology domain containing 6 protein (PLEKHA6) polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients."xsd:string
http://purl.uniprot.org/citations/24576533http://purl.uniprot.org/core/volume"51"xsd:string
http://purl.uniprot.org/citations/24576533http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24576533
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