| http://purl.uniprot.org/citations/24581491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24581491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24581491 | http://www.w3.org/2000/01/rdf-schema#comment | "Global downregulation of microRNAs (miRNAs) is commonly observed in human cancers and can have a causative role in tumorigenesis. The mechanisms responsible for this phenomenon remain poorly understood. Here, we show that YAP, the downstream target of the tumor-suppressive Hippo-signaling pathway regulates miRNA biogenesis in a cell-density-dependent manner. At low cell density, nuclear YAP binds and sequesters p72 (DDX17), a regulatory component of the miRNA-processing machinery. At high cell density, Hippo-mediated cytoplasmic retention of YAP facilitates p72 association with Microprocessor and binding to a specific sequence motif in pri-miRNAs. Inactivation of the Hippo pathway or expression of constitutively active YAP causes widespread miRNA suppression in cells and tumors and a corresponding posttranscriptional induction of MYC expression. Thus, the Hippo pathway links contact-inhibition regulation to miRNA biogenesis and may be responsible for the widespread miRNA repression observed in cancer."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.12.043"xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.12.043"xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Mohseni M."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Mohseni M."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Camargo F.D."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Camargo F.D."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Schlegelmilch K."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Schlegelmilch K."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Shrestha K."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Shrestha K."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Triboulet R."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/author | "Triboulet R."xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/pages | "893-906"xsd:string |
| http://purl.uniprot.org/citations/24581491 | http://purl.uniprot.org/core/pages | "893-906"xsd:string |