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http://purl.uniprot.org/citations/24585893http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24585893http://www.w3.org/2000/01/rdf-schema#comment"

Background

Unlike cytomegalovirus (CMV) infection and aging, human immunodeficiency virus (HIV) decreases the proportion of CD28(-)CD8(+) T cells expressing CD57. Whether this abnormality predicts mortality in treated HIV infection and can be reversed by early antiretroviral therapy (ART) remains unknown.

Methods

We sampled recently HIV-infected individuals (<6 months) and HIV-uninfected controls and compared longitudinal changes in the proportion of CD28(-)CD8(+) T cells expressing CD57 between those who initiated ART early (<6 months) vs later (≥2 years). We also assessed the relationship between this phenotype and mortality in a nested case-control study of ART-suppressed chronically infected individuals.

Results

Compared to HIV-uninfected controls (n = 15), individuals who were recently infected with HIV had lower proportions of CD28(-)CD8(+) T cells expressing CD57 (P < .001), and these proportions increased during ART. The early ART group (n = 33) achieved normal levels, whereas the later ART group (n = 30) continued to have lower levels than HIV-uninfected controls (P = .02). Among 141 ART-suppressed participants in the SOCA study, those in the lowest quartile of CD28(-)CD8(+) T cells expressing CD57 had 5-fold higher odds of mortality than those in the highest quartile (95% CI, 1.6-15.9, P = .007).

Conclusions

Abnormally low proportions of CD28(-)CD8(+) T cells expressing CD57 predict increased mortality during treated HIV infection and may be reversed with early ART initiation."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.org/dc/terms/identifier"doi:10.1093/infdis/jiu109"xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Huang Y."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Jain V."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"McCune J.M."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Lee S.A."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Hunt P.W."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Hecht F.M."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Martin J.N."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Deeks S.G."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Sinclair E."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Lederman M.M."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Epling L."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Van Natta M."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/author"Meinert C.L."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/name"J Infect Dis"xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/pages"374-382"xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/title"Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection."xsd:string
http://purl.uniprot.org/citations/24585893http://purl.uniprot.org/core/volume"210"xsd:string
http://purl.uniprot.org/citations/24585893http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24585893
http://purl.uniprot.org/citations/24585893http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24585893
http://purl.uniprot.org/uniprot/#_Q9P2W7-mappedCitation-24585893http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24585893
http://purl.uniprot.org/uniprot/#_Q8ND18-mappedCitation-24585893http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24585893
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