| http://purl.uniprot.org/citations/24586198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24586198 | http://www.w3.org/2000/01/rdf-schema#comment | "Lifespan is influenced by a large number of conserved proteins and gene-regulatory pathways. Here, we introduce a strategy for systematically finding such longevity factors in Saccharomyces cerevisiae and scoring the genetic interactions (epistasis) among these factors. Specifically, we developed an automated competition-based assay for chronological lifespan, defined as stationary-phase survival of yeast populations, and used it to phenotype over 5,600 single- or double-gene knockouts at unprecedented quantitative resolution. We found that 14% of the viable yeast mutant strains were affected in their stationary-phase survival; the extent of true-positive chronological lifespan factors was estimated by accounting for the effects of culture aeration and adaptive regrowth. We show that lifespan extension by dietary restriction depends on the Swr1 histone-exchange complex and that a functional link between autophagy and the lipid-homeostasis factor Arv1 has an impact on cellular lifespan. Importantly, we describe the first genetic interaction network based on aging phenotypes, which successfully recapitulated the core-autophagy machinery and confirmed a role of the human tumor suppressor PTEN homologue in yeast lifespan and phosphatidylinositol phosphate metabolism. Our quantitative analysis of longevity factors and their genetic interactions provides insights into the gene-network interactions of aging cells."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1004168"xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Deluna A."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Garay E."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Jinich A."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Campos S.E."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Gaspar A.P."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/author | "Gonzalez de la Cruz J."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/pages | "e1004168"xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/title | "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions."xsd:string |
| http://purl.uniprot.org/citations/24586198 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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