Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/24586984http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24586984http://www.w3.org/2000/01/rdf-schema#comment"

Background

Oxidative stress plays an underlying pathophysiologic role in the development of diabetes complications. The aim of this study was to investigate peroxiredoxin 4 (Prx4), a proposed novel biomarker of oxidative stress, and its association with and capability as a biomarker in predicting (cardiovascular) mortality in type 2 diabetes mellitus.

Methods

Prx4 was assessed in baseline serum samples of 1161 type 2 diabetes patients. Cox proportional hazard models were used to evaluate the relationship between Prx4 and (cardiovascular) mortality. Risk prediction capabilities of Prx4 for (cardiovascular) mortality were assessed with Harrell's C statistic, the integrated discrimination improvement and net reclassification improvement.

Results

Mean age was 67 and the median diabetes duration was 4.0 years. After a median follow-up period of 5.8 years, 327 patients died; 137 cardiovascular deaths. Prx4 was associated with (cardiovascular) mortality. The Cox proportional hazard models added the variables: Prx4 (model 1); age and gender (model 2), and BMI, creatinine, smoking, diabetes duration, systolic blood pressure, cholesterol-HDL ratio, history of macrovascular complications, and albuminuria (model 3). Hazard ratios (HR) (95% CI) for cardiovascular mortality were 1.93 (1.57 - 2.38), 1.75 (1.39 - 2.20), and 1.63 (1.28 - 2.09) for models 1, 2 and 3, respectively. HR for all-cause mortality were 1.73 (1.50 - 1.99), 1.50 (1.29 - 1.75), and 1.44 (1.23 - 1.67) for models 1, 2 and 3, respectively. Addition of Prx4 to the traditional risk factors slightly improved risk prediction of (cardiovascular) mortality.

Conclusions

Prx4 is independently associated with (cardiovascular) mortality in type 2 diabetes patients. After addition of Prx4 to the traditional risk factors, there was a slightly improvement in risk prediction of (cardiovascular) mortality in this patient group."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0089719"xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Schulte J."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Bakker S.J."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Struck J."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Gans R.O."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Bilo H.J."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Landman G.W."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Kleefstra N."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Alkhalaf A."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Groenier K.H."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"van Hateren K.J."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/author"Gerrits E.G."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/pages"e89719"xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/title"Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28)."xsd:string
http://purl.uniprot.org/citations/24586984http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/24586984http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24586984
http://purl.uniprot.org/citations/24586984http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24586984
http://purl.uniprot.org/uniprot/#_Q13162-mappedCitation-24586984http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24586984
http://purl.uniprot.org/uniprot/#_V9HW63-mappedCitation-24586984http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24586984
http://purl.uniprot.org/uniprot/Q13162http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24586984
http://purl.uniprot.org/uniprot/V9HW63http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24586984
▶