| http://purl.uniprot.org/citations/24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24587018 | http://www.w3.org/2000/01/rdf-schema#comment | "The formation and remodeling of mossy fiber-CA3 pyramidal cell synapses in the stratum lucidum of the hippocampus are implicated in the cellular basis of learning and memory. Afadin and its binding cell adhesion molecules, nectin-1 and nectin-3, together with N-cadherin, are concentrated at puncta adherentia junctions (PAJs) in these synapses. Here, we investigated the roles of afadin in PAJ formation and presynaptic differentiation in mossy fiber-CA3 pyramidal cell synapses. At these synapses in the mice in which the afadin gene was conditionally inactivated before synaptogenesis by using nestin-Cre mice, the immunofluorescence signals for the PAJ components, nectin-1, nectin-3 and N-cadherin, disappeared almost completely, while those for the presynaptic components, VGLUT1 and bassoon, were markedly decreased. In addition, these signals were significantly decreased in cultured afadin-deficient hippocampal neurons. Furthermore, the interevent interval of miniature excitatory postsynaptic currents was prolonged in the cultured afadin-deficient hippocampal neurons compared with control neurons, indicating that presynaptic functions were suppressed or a number of synapse was reduced in the afadin-deficient neurons. Analyses of presynaptic vesicle recycling and paired recordings revealed that the cultured afadin-deficient neurons showed impaired presynaptic functions. These results indicate that afadin regulates both PAJ formation and presynaptic differentiation in most mossy fiber-CA3 pyramidal cell synapses, while in a considerable population of these neurons, afadin regulates only PAJ formation but not presynaptic differentiation."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0089763"xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Maruo T."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Mandai K."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Togashi H."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Supriyanto I."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/author | "Toyoshima D."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/pages | "e89763"xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/title | "Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24587018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24587018 |
| http://purl.uniprot.org/citations/24587018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24587018 |
| http://purl.uniprot.org/uniprot/#_D3Z7L2-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_E9Q9C3-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_A0A668KLE6-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_F7C3I9-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_E9Q852-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_D3YUD2-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |
| http://purl.uniprot.org/uniprot/#_E9PYX7-mappedCitation-24587018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587018 |