| http://purl.uniprot.org/citations/24587316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24587316 | http://www.w3.org/2000/01/rdf-schema#comment | "Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils. In contrast to Fas, TNF-α inhibited eosinophil apoptosis as evidenced by a combination of flow cytometry, DNA fragmentation assay and morphological analyses. The effect of TNF-α on eosinophil apoptosis was reversed by a TNF-α neutralising antibody. The anti-apoptotic effect of TNF-α was not due to autocrine release of known survival-prolonging cytokines interleukins 3 and 5 or granulocyte-macrophage-colony-stimulating factor as their neutralisation did not affect the effect of TNF-α. The anti-apoptotic signal was mediated mainly by the TNF-receptor 1. TNF-α induced phosphorylation and degradation of IκB and an increase in NF-κB DNA-binding activity. The survival-prolonging effect of TNF-α was reversed by inhibitors of NF-κB pyrrolidinedithiocarbamate and gliotoxin and by an inhibitor of IκB kinase, BMS-345541. TNF-α induced also an increase in AP-1 DNA-binding activity and the antiapoptotic effect of TNF-α was potentiated by inhibitors of AP-1, SR 11302 and tanshinone IIA and by an inhibitor of c-jun-N-terminal kinase, SP600125, which is an upstream kinase activating AP-1. Our results thus suggest that TNF-α delays human eosinophil apoptosis via TNF-receptor 1 and the resulting changes in longevity depend on yin-yang balance between activation of NF-κB and AP-1."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0090298"xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Barnes P.J."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Adcock I.M."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Moilanen E."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Lahti A."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Giembycz M.A."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Kankaanranta H."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Lindsay M.A."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/author | "Ilmarinen P."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/pages | "e90298"xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/title | "Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1."xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24587316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24587316 |
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| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-24587316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24587316 |
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